Options for


Endometriosis is such a variable condition that individualisation of the approach to management is important in all cases.

Treatment approaches of endometriosis could involve non-surgical or surgical treatments or both.

Traditional Medical Treatment

First line treatment

  • Non-steroidal anti-inflammatories ( NSAIDs )
  • Cyclic oral contraception

Second line treatment

  • Continuous oral contraception
  • Progestogens such as visane
  • Danazole

Third line treatment

  • GnRH agonist or antagonist with or without add-back estrogen therapy
  • Aromatase inhibitors such as Letrozole

Modern non-surgical (medical) approaches

  • Selective estrogen receptors modulators (SERMS) such as TZE 5323
  • Selective progesterone receptor modulators (SPRMS) such as J867, J912
  • Anti-angiogenesis such as ICON
  • Statins (anti-oxidants)

Conservative surgery for endometriosis

Laparoscopic excision of endometriosis can reduce endometriosis related pain by 75%.

Conservative laparoscopic surgeries for infertility related endometriosis such as excision of endometriosis, excision of endometrioma or release of adhesions can improve pregnancy rates

  • 67-75% cumulative pregnancy rates in three years after treating mild disease
  • 20-75% pregnancy rates after treating severe or advanced disease
  • Improved pregnancy rates for laparoscopic surgery after failed IVF

Radical treatment

Endometriosis population are merely young women in their reproductive age, all measures should be exhausted to preserve their uterus & ovaries, however for advanced cases/recurrent cases or cases who have completed their families, Hysterectomy + removal of both ovaries could be the last resort of treatment.

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